
What it is
A signal from your mitochondria
Most of your DNA lives in the cell's nucleus. MOTS-c is coded in the small genome inside your mitochondria, and researchers describe it as a hormone-like signal that can travel through the body.Lee et al., Cell Metabolism, 2015

In mice
What the first studies found
In mice, MOTS-c switched on AMPK, a cellular energy sensor. It improved insulin sensitivity and prevented weight gain on a high-fat diet. These effects have not been proven in people.Lee et al., Cell Metabolism, 2015

Exercise-linked
Your body makes more when you move
In people, MOTS-c levels in muscle and blood rose with exercise. In older mice, MOTS-c treatment improved physical capacity. Treatment hasn't been tested this way in humans.Reynolds et al., Nature Communications, 2021
MOTS-c is investigational and not FDA-approved. Large human trials have not been completed.